Due to the length of the book that contains so much details leading so mini climaxes, I think this will be better to be made into mini series rather than just a blockbuster movie.
There are few examples of other great novels that lost their taste or characters when made into single movie. I think 11/22/63 will do better in mini series tho the revenue will be much slower or less than a movie.
Or make it into two versions: single movie and mini series; where the single movie is played by the same casts from the mini series but it will be very compact (it might go more than 2h30m for sure).
Just my 2 cents.