Always go for the headshot. Whether it's a zombie or a psycho-killer a .357 or .45 caliber round to the noggin' will put them down permanently.
Take Joey Ramone's advice and tell your friend, lover, sibling, parent, etc. "I Don't Wanna Go Down To The Basement"!
Vampires are not poor, tortured, misunderstood beings that sparkle. They are soulless, blood sucking, freaks and should be treated and disposed of a such!